Excision
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Junction
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Mutation
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|---|
|  | V | D | J |  | μ | σ | Probability | (0-95%) |
|  | μ | σ | μ | σ | μ | σ | VD | 2 | 1 | Indel |
Start (5’) | 8 | 2 | 5 | 1 | 7 | 2 | DJ | 2 | 1 | Number | Random (usually 1) |
End (3’) | 2 | 1 | 2 | 1 | 13 | 3 |  |  |  | Mean Length | 4 |
- The amount of excision and addition for an artificial rearrangement are randomly selected from a normal distribution. The μ and σ are the means and standard deviations. Indel lengths are selected from Poisson distribution, therefore only a mean is needed. The number of indels is selected from a distribution of the form P(n) = cne-3n to require an indel, but heavily weight n = 1. Location of indels are randomly selected.
