Table 5 Enrichment of the predicted driver proteins among disease-associated genes
From: Determining minimum set of driver nodes in protein-protein interaction networks
| Â | Â | intlinprog | lp_solve | ||
|---|---|---|---|---|---|
Database | Dataset (# proteins) | MDS | CC-MDS | MDS | CC-MDS |
| Â | Combined (1071) | 6.7E-04 (222) | 2.3E-14 (274) | 2.2E-08 (249) | 2.3E-14 (274) |
GAD | Binary (1020) | 1.1E-02 (210) | 5.6E-14 (270) | 1.5E-09 (252) | 5.6E-14 (270) |
| Â | Co-complex (487) | 1.5E-02 (118) | 3.2E-08 (144) | 3.6E-05 (132) | 3.2E-08 (144) |
| Â | Combined (1639) | 4.7E-07 (349) | 2.0E-12 (378) | 5.2E-08 (355) | 1.1E-12 (379) |
OMIM | binary (1558) | 2.0E-02 (308) | 5.5E-10 (362) | 5.9E-08 (351) | 3.4E-10 (363) |
| Â | Co-complex (657) | 3.0E-03 (159) | 3.2E-07 (179) | 2.0E-05 (171) | 3.2E-07 (179) |
| Â | Combined (1686) | 2.5E-05 (346) | 2.9E-09 (371) | 1.9E-06 (354) | 1.9E-09 (372) |
Uniport | binary (1604) | 1.6E-03 (328) | 5.5E-08 (360) | 5.9E-07 (354) | 3.6E-08 (361) |
| Â | Co-complex (711) | 6.5E-03 (168) | 4.3E-05 (181) | 8.8E-04 (174) | 4.3E-05 (181) |