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Figure 3 | BMC Bioinformatics

Figure 3

From: DisCons: a novel tool to quantify and classify evolutionary conservation of intrinsic protein disorder

Figure 3

Analyzing SLiMs with DisCons. Short linear motifs (SLiMs) are peptide motifs with characteristic sequence patterns and are generally enriched in disorder. As displayed on panel A with the help of normalized density curves, SLiMs are significantly more disordered than the full length proteins they are found in or compared to the proteins found in DisProt. Not only are SLiMs more disordered, but this flexibility is highly conserved across homologs as well (panel B, left). When compared to the IDPs of DisProt (panel B, right) the difference in conservation is striking. As in FigureĀ 2B, disorder- and sequence conservation scores range from 0 (not conserved) to 1 (conserved at all positions in the multiple sequence alignment).

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