Figure 4
From: MONALISA for stochastic simulations of Petri net models of biochemical systems
Results of a 48 h simulation of the IR model. The IR cycling model was simulated for two days with a typical insulin profile. The basal insulin level is 6·10−11 M. At 09:00 h, 13:00 h and 18:00 h, meal intake stimulates insulin secretion and leads to a peak postprandial concentration of 3.6·10−10 M which returns to its basal state within three hours. The numbers of insulin molecules (upper part) and the number of molecules of different states (lower part) are plotted against the simulated time. Black points represent insulin, red points the free membrane located receptor, blue points the receptor-insulin complex (inactive), green the free receptor in cytosol, yellow the activated phosphorylated IR-insulin complex in cytosol and cyan the phosphorylated receptor-insulin complex in the membrane.