Figure 3

Estimates \( {\widehat{\theta}}_i \) of methylation pattern abundances calculated using MPFE from the synthetic dataset of Figure 2 assuming, in panels (A) and (C), a range of non-conversion rates ε and the correct sequencing error rate η=0.02, and, in panels (B) and (D) the correct non-conversion rate ε=0.01 and a range of sequencing error rates η. Pattern numbers in the legends correspond to the horizontal axis of Figure 2. In panels (A) and (B) the 10 ‘true’ patterns are highlighted on colour. Panels (C) and (D) show an expanded view of the lower part of the plot with examples of patterns occuring at low frequencies (both spurious and non-spurious) highlighted in colour: 2 real patterns (24 and 31), 3 spurious patterns which are reported as real in Figure 2 (namely 2, 45 and 53), and 2 spurious patterns which are correctly identified in Figure 2 (namely 9 and 42).