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Table 1 New GO terms created to support detailed ASD-relevant annotations. The ancestral relationship of these new GO terms is described in Figs. 4 and 5 (with the exception of the new protein binding terms and ‘receptor localization to synapse’). The term records in the QuickGO browser (http://www.ebi.ac.uk/QuickGO) provide the full definition and ontology placement for each GO term provide the full definition and ontology placement for each GO term. The reference column lists the references used as a source of information when creating each term

From: Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism

New GO Term

GO ID

Reference

Synapse assembly terms

Postsynaptic density assembly

GO:0097107

[65]

Postsynaptic density organization

GO:0097106

[65]

Postsynaptic membrane assembly

GO:0097104

[39]

Presynaptic membrane assembly

GO:0097105

[56, 68]

Presynaptic membrane organization

GO:0097090

[49]

Regulation of postsynaptic membrane potential terms

Negative regulation of excitatory postsynaptic membrane potential

GO:0090394

[49]

Positive regulation of excitatory postsynaptic membrane potential

GO:2000463

[77]

Positive regulation of inhibitory postsynaptic membrane potential

GO:0097151

[68]

Protein clustering/localization terms

Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering

GO:0097113

[35]

Gamma-aminobutyric acid receptor clustering

GO:0097112

[48]

Gephyrin clustering involved in postsynaptic density assembly

GO:0097116

[48]

Guanylate kinase-associated protein clustering

GO:0097117

[48]

Neurexin clustering involved in presynaptic membrane assembly

GO:0097115

[35]

Neuroligin clustering involved in postsynaptic membrane assembly

GO:0097118

[35]

N-methyl-D-aspartate receptor clustering

GO:0097114

[48]

Postsynaptic density protein 95 clustering

GO:0097119

[80]

Receptor localization to synapse

GO:0097120

[65]

Protein binding terms

Neuroligin family protein binding

GO:0097109

[39]

Scaffold protein binding

GO:0097110

[80]