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Table 3 Selection of the molecular function GO terms associated with the ASD-relevant human proteins

From: Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism

GO term name

NLGN1

NLGN2

NLGN3

NLGN4X

NLGN4Y

NRXN1-α

NRXN1-β

NRXN2-α

NRXN2-β

NRXN3-α

NRXN3-β

CNTNAP1

SHANK1

SHANK2

SHANK3

DLG4

cell adhesion molecule binding

X

X

X

X

X

X

X

X

X

X

X

     

receptor activity

X

X

X

X

X

X

X

X

X

X

X

X

    

neurexin family protein binding

X

X

X

X

X

           

neuroligin family protein binding

     

X

X

X

X

X

X

    

X

calcium channel regulator activity

     

X

X

X

 

X

      

acetylcholine receptor binding

     

X

         

X

GKAP/Homer scaffold activity

            

X

X

X

 

scaffold protein binding

  

X

X

X

       

X

 

X

X

receptor signaling complex scaffold activity

            

X

   

ionotropic glutamate receptor binding

            

X

X

X

X

somatostatin receptor binding

            

X

   

beta-1 adrenergic receptor binding

               

X

D1 dopamine receptor binding

               

X

P2Y1 nucleotide receptor binding

               

X

  1. X indicates the existence of an association between the GO term and the human protein record; all associations (except IEA-supported data) are included (see Additional file 6)
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BMC Bioinformatics

ISSN: 1471-2105

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