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Fig. 5 | BMC Bioinformatics

Fig. 5

From: GPCRtm: An amino acid substitution matrix for the transmembrane region of class A G Protein-Coupled Receptors

Fig. 5

Example of pairwise alignments of the adenosine AA2AR and sphingosine-1-phosphate S1PR1 amino acid sequences using: GPCRtm (a), JTTtm (b), PHAT (c), BLOSUM62 (d) and BLOSUM45 (e) substitution matrices. Transmembrane regions TM 1 to 7 appear outlined in red according on the crystallographic 3D structural data for each receptor (PDBid: 3EML and 3V2Y). Pairwise sequence alignments were done with MAFFT program [35]

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BMC Bioinformatics

ISSN: 1471-2105

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