Table 3 Results of BLASTP database searches using the nine human adrenergic receptor subtypes as queries against the Protein Data Bank. The table displays only the first hit (lower E-value) of each search (IUPAC name of the receptor and PDBid code in parenthesis) followed by the sequence identity values in the aligned regions and the corresponding bit scores for the GPCRtm and general substitution matrices
| Â | GPCRtm | JTT | PHAT | BLOSUM62 | BLOSUM45 | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Query Receptor | First Hit | Id. (%) | Score (bits) | E-value | First Hit | Id. (%) | Score (bits) | E-value | First Hit | Id. (%) | Score (bits) | E-value | First Hit | Id. (%) | Score (bits) | E-value | First Hit | Id. (%) | Score (bits) | E-value |
ADA1A | ADRB1 (2VT4) | 34 | 140.9 | 1.0e−55 | ACM2 (4MQS) | 30 | 140.0 | 2.3e−55 | ADRB2 (3KJ6) | 36 | 226.3 | 8.8e−62 | 5HT1B (4IAQ) | 35 | 133.9 | 7.5e−57 | 5HT1B (4IAQ) | 35 | 140.9 | 5.0e−59 |
ADA1B | ADRB1 (2VT4) | 35 | 139.4 | 3.5e−56 | ADRB1 (2VT4) | 34 | 133.9 | 4.8e−59 | ADRB2 (3KJ6) | 34 | 215.3 | 3.5e−58 | ADRB1 (2Y00) | 35 | 139.3 | 1.1e−55 | ADRB1 (2Y00) | 35 | 141.2 | 4.6e−56 |
ADA1D | ADRB1 (2VT4) | 35 | 154.3 | 3.3e−58 | ADRB1 (2VT4) | 35 | 133.9 | 4.8e−56 | ADRB1 (2VT4) | 36 | 156.6 | 1.6e−60 | ADRB1 (2VT4) | 36 | 150.4 | 1.0e−57 | ADRB1 (2VT4) | 36 | 150.3 | 9.1e−58 |
ADA2A | ADRB1 (2VT4) | 40 | 130.4 | 6.0e−50 | ACM2 (4MQS) | 26 | 126.8 | 4.2e−49 | ADRB2 (3D4S) | 29 | 163.5 | 8.8e−53 | 5HT1B (4IAR) | 39 | 144.3 | 5.3e−56 | 5HT1B (4IAQ) | 41 | 147.0 | 1.0e−57 |
ADA2B | ADRB2 (2R4S) | 30 | 128.9 | 8.1e−47 | DRD3 (3PBL) | 30 | 195.8 | 4.5e−53 | DRD3 (3PBL) | 31 | 215.9 | 1.3e−56 | 5HT1B (4IAR) | 36 | 135.4 | 8.0e−55 | 5HT1B (4IAR) | 36 | 142.9 | 2.1e−58 |
ADA2C | ADRB1 (2VT4) | 35 | 118.5 | 1.2e−49 | ADRB1 (2VT4) | 34 | 108.1 | 5.1e−49 | ADRB1 (2VT4) | 37 | 130.2 | 2.8e−53 | 5HT1B (4IAR) | 35 | 134.7 | 6.8e−56 | 5HT1B (4IAR) | 34 | 139.4 | 1.7e−58 |
ADRB1 | ADRB1 (2Y00) | 77 | 308.0 | 2.6e−135 | ADRB1 (3KJ6) | 57 | 241.1 | 1.5e−99 | ADRB1 (2Y00) | 77 | 338.1 | 1.1e−148 | ADRB1 (2Y00) | 77 | 317.4 | 2.5e−130 | ADRB1 (2Y00) | 77 | 319.6 | 2.9e−132 |
ADRB2 | ADRB2 (2R4R) | 99 | 696.1 | 5.1e−204 | ADRB2 (2R4R) | 99 | 624.7 | 3.4e−182 | ADRB2 (2R4R) | 99 | 791.0 | 2.3e−232 | ADRB2 (2R4R) | 99 | 686.4 | 1.2e−200 | ADRB2 (2R4R) | 99 | 678.6 | 2.1e−198 |
ADRB3 | ADRB1 (2Y00) | 53 | 201.6 | 2.3e−86 | ADRB1 (2Y00) | 53 | 185.2 | 3.7e−78 | ADRB1 (2Y00) | 56 | 220.0 | 2.4e−95 | ADRB1 (2Y00) | 56 | 215.7 | 6.6e−89 | ADRB1 (2Y00) | 56 | 217.6 | 2.4e−90 |