Fig. 7
From: A simplicial complex-based approach to unmixing tumor progression data
Minimum spanning tree of simplicial complex derived from the TCGA data and a model of the data as a phylogeny. We compute the minimum spanning tree of the simplicial complex found during unmixing of the RNASeq data to learn the phylogeny of subpopulations inferred by the simplicial complex unmixing. Labels for the vertices carry over from the previous figure and Table 1. We use the minimum spanning tree to define tree structure among the vertices. We label each vertex manually based on examination of the simplicial complex fit and the DAVID categories associated with the vertices. We note that although population 1 is included where it is assigned in the tree, we speculate that it reflects infiltration of immune cells not phylogenetically related to the tumor cell populations