| | | |
VIF Estimate
|
Type-I Error
|
|---|
|
Sample Size
|
Percent Conf.
|
True VIF
|
QuSAGE
|
Q-Gen
|
Qusage
|
Q-Gen
|
|---|
|
5
|
0
|
20.024
|
19.04
|
18.89
|
.046
|
.054
|
|
5
|
.25
|
20.024
|
17.43
|
18.87
|
.042
|
.050
|
|
5
|
.5
|
20.024
|
17.89
|
18.89
|
.041
|
.055
|
|
5
|
0
|
6.435
|
6.20
|
6.16
|
.044
|
.050
|
|
5
|
.25
|
6.435
|
6.282
|
6.2
|
.040
|
.054
|
|
5
|
.5
|
6.435
|
8.04
|
6.16
|
.045
|
.055
|
|
5
|
0
|
1
|
0.99
|
0.99
|
.048
|
.053
|
|
5
|
.25
|
1
|
1.72
|
1.00
|
.041
|
.054
|
|
5
|
.5
|
1
|
4.16
|
0.99
|
.010
|
.057
|
|
15
|
0
|
20.024
|
19.75
|
19.74
|
.047
|
.047
|
|
15
|
.25
|
20.024
|
18.72
|
19.72
|
.056
|
.049
|
|
15
|
.5
|
20.024
|
18.59
|
19.71
|
.0822
|
.053
|
|
15
|
0
|
6.435
|
6.36
|
6.36
|
.053
|
.052
|
|
15
|
.25
|
6.435
|
6.43
|
6.36
|
.072
|
.052
|
|
15
|
.5
|
6.435
|
8.27
|
6.34
|
.101
|
.051
|
|
15
|
0
|
1
|
1.00
|
1.00
|
.048
|
.049
|
|
15
|
.25
|
1
|
1.719
|
1.00
|
.097
|
.050
|
|
15
|
.5
|
1
|
4.176
|
1.00
|
.074
|
.051
|
- VIF and type-I error estimates under a case-control simulation in the presence of a confounding variable where the percentage of genes that are affected by the confounder are examined for 0, 25, and 50 % respectively. Error rates in bold indicate they are within the margin of error (0.05 ± 0.00427) for the simulation study. Since Q-Gen allows for a linear model that adjusts for covariates, VIF estimation and the controlling of the type-I error is more consistent than the standard two sample t-testing conducted within QuSAGE
