|
Parameter
|
Value
|
Description
|
|
μ
|
0.02 m
i
n
−1
|
Bacterial growth rate.
|
|
D
|
2 m
b
p
|
Lac promoter concentration.
|
|
k
M
|
180 m
i
n
−1
|
Maximal transcription initiation rate of the lac promoter.
|
|
k
E
|
18.8 m
i
n
−1
|
Translation initiation rate of lacZ transcript.
|
|
k
L
|
6.0×104
m
i
n
−1
|
Maximal lactose uptake rate per permease.
|
|
γ
M
|
0.48 m
i
n
−1
|
lacZ mRNA dilution/degradation rate.
|
|
γ
E
|
0.03 m
i
n
−1
|
Lac permease degradation/dilution rate.
|
|
γ
L
|
0.02 m
i
n
−1
|
Lactose degradation/dilution rate.
|
|
k
pc
|
30
|
Cooperative promoter-CAP binding site interaction
|
|
p
p
|
0.127
|
Polymerase binding probability to the lac promoter.
|
|
ϕ
M
|
3.6 ×104
m
i
n
−1
|
Max. rate of lac-to-allolac and lac-to-gal metabolism
|
|
K
G
|
2.6 μ
M
|
CAP complex binding affinity to DNA based on external glucose concentration.
|
|
n
h
|
1.3
|
CAP complex binding affinity to external glucose.
|
|
ξ
2
|
0.05
|
Affinity of active repressor for Operator O
2.
|
|
ξ
3
|
0.01
|
Affinity of active repressor for Operator O
3.
|
|
ξ
123
|
163
|
Stability of the O
1- O
2- O
3-repressor complex.
|
|
ρ
max
|
1.3
|
Repression affinity of lac operon promoter
|
|
K
A
|
2.92 ×106
m
p
b
|
Allolactose-repressor subunit dissociation rate.
|
|
k
L
|
680 μ
M
|
Half-saturation constant for lactose uptake rate.
|
|
ϕ
G
|
0.35
|
Permease activity as a function of inside glucose concentration
|
|
k
G
|
1.0 μ
M
|
Permease activity as a function of outside glucose concentration.
|
|
k
M
|
7.0 ×105
m
p
b
|
Max. transcription initiation rate of lac promoter
|
