Fig. 4

Comparison of E-Box motifs of Max, Myc, and Mad using DiffLogo. We plot all pair-wise difference logos and display the distance between each motif using the background color from green (similar) to red (dissimilar). We plot the sequence logos of each motif as well as the leaf-ordered cluster tree above. The motifs of the transcription factors Myc and Mad are more similar to each other than to the motif Max. The six core nucleotides with consensus sequence CACGTG are conserved in the motifs of all three transcription factors and, hence, are not visible in the difference logos