Fig. 6
From: HMMvar-func: a new method for predicting the functional outcome of genetic variants
Distance tree of the MAP2K subfamilies. Colors indicate different subfamilies. The minimum score \({S_{i}^{x}}\) is calculated from C 19. C 0 is the target cluster. C 28 is an example subfamily that the mutant protein could switch to. The leaves are protein sequences. Two sequences are merged according to the BLOSUM62 matrix by averaging the substitution distance over all the positions in the MSA. The numeric prefix of a sequence ID is the cluster number