Fig. 5

Boxplots of conservation scores for enumerated and known metabolic paths. For paths of length 2 (two edges and three nodes) in the RMS-H2 network, distributions of the three conservation scores (i.e. scoreRea, scoreProt and scorePageRank) are presented in all possible paths from the RMS network (identified as “All paths” in the figure) versus paths solely included in known metabolic pathways (“Known metabolic pathways”). The latter present significant higher scores (p-value <2e ⁻¹⁶ using Tukey’s HSD tests)