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Table 3 Performance on HIV plasmid mixture dataset 1

From: QQ-SNV: single nucleotide variant detection at low frequency by comparing the quality quantiles

 

QQ-SNVD

QQ-SNVHS-P80 a

LoFreq

ShoRAH

V-Phaser 2

Variant %

sens.b

sens.b

sens.b

sens.b

sens.b

 88.889 %

57/61

60/61

59/61

56/61

20/61

 10 %

44/50

49/50

47/50

45/50

13/50

 1 %

28/34

30/34

23/34

26/34

10/34

 0.1 %

2/42

20/42

0/42

7/42

22/42

 0.01 %

0/40

1/40

0/40

3/40

8/40

 0.001 %

0/30

0/30

0/30

0/30

0/30

 

FPc

FPc

FPc

FPc

FPc

 

2

4

0

6

2

 

timede

timede

timedf

timedg

timedg

 

14m11s

14m11s

53m24s

6h25m

33m5s

  1. a80th percentile of the QQ-SNVHS distribution of “error” frequencies was used as frequency cutoff to decrease the number of false positives obtained with QQ-SNVHS
  2. bsens. is the percentage of true variants that were correctly called as SNV
  3. cFP is the number of variants incorrectly called as SNV
  4. dcomputation time in hours (h), minutes (m) and seconds (s)
  5. eWindows 7 64 bit, 8GB RAM, 3.2GHz
  6. fLinux Ubuntu 12.04.4, 57.6 GB RAM, one core (2.3GHz) used
  7. gLinux Ubuntu 12.04.4, 57.6 GB RAM, 8 cores (2.3GHz) used in parallel