Fig. 7
From: Unsupervised image segmentation for microarray spots with irregular contours and inner holes
Selection of up-regulated spots that have not been identified by the standard approach of GenePix: spot no. a 2321, b 13,150, c 6294, d 4648 on microarray ID 20385, spot no. e 1317 and f 6728 on microarray ID 20391 and spot no. g 4422 on microarray ID 20392. Our approach allows for the irregular contours and the non-homogeneous intensity distributions of these spots. Standard approximations of the bright foreground areas based on the simple geometric forms of ellipses are problematic