Table 2 Pathways enriched by differentially expressed genes among TB, LTBI, and healthy control (HC)
From: Gene expression profiling identifies candidate biomarkers for active and latent tuberculosis
KEGG pathway | ID | Genes |
|---|---|---|
TB vs. HC | ||
 Cytokine-cytokine receptor interaction | 04060 | CCR6, IL7R, CCR7, FLT1, CCR2, TNFSF13B, FASLG, IL2RB, CD27, IL23A, TGFBR2 |
 Rheumatoid arthritis | 05323 | TLR4, IL23A, HLA-DOB, ATP6V0E2, FLT1, TNFSF13B |
 Pathways in cancer | 05200 | MYC, ITGA6, FASLG, RASSF5, HSP90AA1, CASP8, TRAF4, TRAF5, TGFBR2, ETS1 |
 Graft-versus-host disease | 05332 | FASLG, KLRC1, PRF1, HLA-DOB |
 MAPK signaling pathway | 04010 | FASLG, RRAS2, TGFBR2, MYC, RASA2, PRKACB, MAP3K1 |
LTBI vs. HC | ||
 MAPK signaling pathway | 04010 | TNF, JUN, DUSP2, ATF4, NR4A1, FOS, DUSP5, DDIT3, PDGFRB, DUSP1 |
 Adipocytokine signaling pathway | 04920 | POMC, TNF, STK11, CAMKK2, NFKBIA, SOCS3 |
 Leishmaniasis | 05140 | TNF, JUN, FOS, NFKBIA |
 Toll-like receptor signaling pathway | 04620 | TNF, JUN, FOS, NFKBIA |
 Cytokine-cytokine receptor interaction | 04060 | TNF, CXCL2, TNFSF14, PDGFRB, OSM |
LTBI vs. TB | ||
 Chemokine signaling pathway | 04062 | GSK3B, CCR6, CXCL16, ARRB2, PIK3CG, NFKBIA, PRKACB |
 Apoptosis | 04210 | CASP8, PIK3CG, NFKBIA, TNFRSF10B, PRKACB |
 T cell receptor signaling pathway | 04660 | GSK3B, PTPRC, FOS, PIK3CG, NFKBIA |
 Toll-like receptor signaling pathway | 04620 | LY96, CASP8, FOS, PIK3CG, NFKBIA |
 B cell receptor signaling pathway | 04662 | GSK3B, FOS, PIK3CG, NFKBIA |