From: ChainRank, a chain prioritisation method for contextualisation of biological networks
Application case | Network properties | Gold standard (GS) | Start protein | End protein | GS representation | ||
---|---|---|---|---|---|---|---|
Edges | Nodes | Nodes | Edges | ||||
Human PPI network | 61872 | 10167 | IGF-Akt pathway | - | - | 13 | 20 |
COPD specific MAPK | - | - | 21 | 34 | |||
Muscle specific case | 847 | 308 | IGF-Akt pathway | IGF1 | RPS6KB1 | 9 | 10 |
COPD related case | 544 | 152 | COPD specific MAPK | EGFR | SRF, CREBBP, ELK1, MYC | 11 | 8 |