Table 2 Average accuracy (error rate) and average size of the gene panel (number of selected genes) selected by automated predictors of infected state (class) for different viral challenges (data from DEE2/DEE5, DEE3/DEE4 and HRV-UVA/HRV-Duke were pooled and designated as H3N2, H1N1, and HRV in table). Shown are the reference-aided predictor (w/ baseline reference), the standard predictor (w/o baseline reference), the standard predictor with constraints to have the similar complexity in terms of the number of genes as the reference-aided predictor (constrained standard predictor), and the differential predictor. Across all viruses the inclusion of the baseline reference results in a decrease in error rate and a reduction in the number of genes used by the predictor. The reported accuracy and size of panel were computed by cross-validation of the predictors using leave-one-subject-out resampling to partition the data into training and target samples

From: An individualized predictor of health and disease using paired reference and target samples