Fig. 3

The small molecule Nutlin interferes with the MDM2-TP53 interaction. a Structure of Nutlin (yellow) binding to MDM2 (green), of the MDM2 (green)/P53 (blue) complex. The alignment of the structures shows that the P53 peptide and Nutlin interact with the same binding pocket. b Interaction contacts in the genome browser. The bottom track (black) displays the MDM2 transcripts. The other tracks display the contacts between MDM2 and one or more molecules. Dark blue tracks: protein-protein contacts from experimental structures. Green track: Nutlin-MDM2 contacts from experimental structure. Turquoise track: interaction between the Nutlin-MDM2 and the P53-MDM2 tracks. Orange tracks: contacts from models. A zoom on the intersection track evidences several MDM2 residues in contacts with both Nutlin and P53, including G58