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Fig. 6 | BMC Bioinformatics

Fig. 6

From: Analysing multiple types of molecular profiles simultaneously: connecting the needles in the haystack

Fig. 6

Gene GGT7: expression, methylation and copy number. mRNA expression (y-axis) of one probe mapping to gene GGT7 in the colon cancer data. Top graphs: methylation values (logit of beta values) for chosen probes within 50 Kb of the gene start site; point colours represent the dychotomized copy number (see legend and dashed line in the graph right below), with blue corresponding to approximately diploid number of copies; the vertical dashed line represents the cut-off used to separate samples with more or less methylation. Middle graphs: median copy number values across all measurements within the 1 Mb region around the gene start site; point colours represent the dychotomized methylation (see legend and dashed line in the graph right above), with blue corresponding to less methylation; the vertical dashed line represents the cut-off used to separate samples approximately diploid from those. Bottom graph: mRNA expression for all samples, sorted from the smallest to the largest; three plotting symbols are used per sample to convey dychotomized copy number (star), methylation probe 1 (upwards triangle) and methylation probe 2 (downwards triangle); symbol colours are blue for lower values (diploid copy number, less methylation) or pink (copy gain, more methylation), as before

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