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Table 2 Genes from the best COXEN models for predicting clinical response to doxorubicin and carboplatin in the COS33

From: Intra- and interspecies gene expression models for predicting drug response in canine osteosarcoma

Model Gene symbol Gene title Function
Doxorubicin model NCI60-COS16-COS16-COS33 CHKA Choline kinase alpha Phospholipid biosynthesis, tumor cell growth
TLE1 Transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) Transcriptional co-repressor; inhibits NF-kappa-B expression and WNT signaling
EIF6 Eukaryotic translation initiation factor 6 Helps ITGBB4 link to cytoskeleton
TES Testis derived transcript (3 LIM domains) Scaffold protein; role in cell adhesion, cell spreading, reorganization of actin cytoskeleton, regulates cell proliferation, may act as a tumor suppressor
Carboplatin model FACC-COS16-FACC-COS33 OCA2 Oculocutaneous albinism II Transporter of tyrosine within the melanocyte, may determine eye and skin color
HES3 Hairy and enhancer of split 3 (Drosophila) Transcriptional repressor of genes that require bHLH protein for their transcription
LOC100688725 Uncharacterized Cytochrome C oxidase Cytochrome C oxidase activity
PSMD3 Proteasome (prosome, macropain) 26 s subunit, non-ATPase, 3 Involved in ATP-dependent degradation of ubiquinated proteins
cOR4F25 cOR4F25 olfactory receptor family 4 subfamily F-like Involved in canine olfactory system
KIAA0922 Transmembrane protein 131-like Integral transmembrane protein, possible involvement in immune responses