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Table 4 The Gene Ontology results of the subnetwork identified by RLRNPI-AEN for dataset GSE1456

From: Regularized logistic regression with network-based pairwise interaction for biomarker identification in breast cancer

Subnetwork GO number Ontology description Adjusted p-value
TFG GPRASP1 TAC3 OFD1 GO:0043015 gamma-tubulin binding 3.07×10−2
  GO:0043014 alpha-tubulin binding 3.07×10−2
SPTAN1 CRK FANCA GO:0045309 protein phosphorylated amino acid binding 3.02×10−2
  GO:0030507 spectrin binding 3.02×10−2
  GO:0046875 ephrin receptor binding 3.02×10−2
  GO:0042169 SH2 domain binding 3.02×10−2
  GO:0051219 phosphoprotein binding 3.48×10−2
BACH2 ATF7 JUN GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding 2.61×10−4
  GO:0001012 RNA polymerase II regulatory region DNA binding 2.61×10−4
  GO:0000976 transcription regulatory region sequence-specific DNA binding 2.61×10−4
  GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity 2.61×10−4
  GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 2.61×10−4
  1. The first column (Subnetwork) presents the elements of subnetwork of which the functional and biological relationship are analyzed based on the GO annotation