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Table 2 This table summarizes how many of the structures identified as having a significant cluster by one of the quaternary methodologies also had a subunit that had at least one damaging (in the case of Polyphen-2) or driver (in the case of CHASM) mutation

From: Leveraging protein quaternary structure to identify oncogenic driver mutations

  Polyphen-2 CHASM Total flagged
Method Benign Possibly damaging Probably damaging FDR ≤ 0.2 by quaternary approach
(1) (2) (3) (4) (5) (6)
iPAC 198 11 134 78 343
GraphPAC 198 11 120 89 329
SpacePAC 198 11 118 74 327
  1. Column (1) specifies the quaternary methodology used and column (6) denotes how many total structures were flagged using that quaternary approach. Columns (3)-(5) break out the results by the specific machine learning approach