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Table 7 The table shows the specificity (Sp), sensitivity (Sn), true positives (TP), true negatives (TN), false negatives (FN), false positives (FP) and area under the ROC and PRC curves (auROC/PRC) as well as the time needed for obtaining the best combination for all methods and the five studied chromosomes for stop codon recognition

From: Stepwise approach for combining many sources of evidence for site-recognition in genomic sequences

Chromosome Objective Method Combination auROC auPRC G Sp Sn TP FN TN FP #models Time(s)
Chr. 1 - Std - 0.9280 0.0142 0.8487 0.8942 0.8055 1735 419 21,077,932 2,495,099 - -
  auROC Cons Sum 0.9705 0.0368 0.8868 0.9707 0.8101 1745 409 22,882,052 690,979 4 4818
  auPRC Cons Sum 0.9522 0.0525 0.8165 0.9762 0.6829 1471 683 23,011,801 561,230 22 9702
  G Cons Majority 0.9307 0.0013 0.9207 0.9426 0.8993 1937 217 22,218,892 1,354,139 2 1223
Chr. 3 - Std - 0.9233 0.0083 0.8256 0.9159 0.7442 829 285 19,711,889 1,810,611 - -
  auROC Cons Sum 0.9720 0.0262 0.8959 0.9676 0.8294 924 190 20,826,101 696,399 4 4,094
  auPRC Cons Sum 0.9421 0.0297 0.7810 0.9735 0.6266 698 416 20,951,286 571,214 10 8019
  G Cons Majority 0.9584 0.0015 0.9128 0.9462 0.8806 981 133 20,364,397 1,158,103 4 1719
Chr. 13 - Std - 0.9185 0.0071 0.8150 0.9103 0.7297 243 90 9,902,079 976,223 - -
  auROC Cons Sum 0.9585 0.0156 0.8817 0.9733 0.7988 266 67 10,587,495 290,807 5 4542
  auPRC Cons Sum 0.9392 0.0311 0.7604 0.9824 0.5886 196 137 10,687,114 191,188 20 9136
  G Cons Majority 0.9502 0.0106 0.8878 0.9545 0.8258 275 58 10,383,296 495,006 6 1619
Chr. 19 - Std - 0.9328 0.0379 0.8515 0.8664 0.8368 1190 232 4,042,574 623,230 - -
  auROC Cons Sum 0.9731 0.0843 0.9160 0.9335 0.8987 1278 144 4,355,655 310,149 5 3878
  auPRC Cons Sum 0.9557 0.1119 0.8787 0.9250 0.8347 1187 235 4,316,077 349,727 15 8806
  G Cons Majority 0.9346 0.0026 0.9169 0.9002 0.9339 1328 94 4,199,984 465,820 2 856
Chr. 21 - Std - 0.8890 0.0083 0.7778 0.9191 0.6582 156 81 3,425,375 301,584 -  
  auROC Cons Sum 0.9674 0.0383 0.8797 0.9654 0.8017 190 47 3,597,983 128,976 4 2379
  auPRC Cons Sum 0.9455 0.0382 0.7970 0.9713 0.6540 155 82 3,620,079 106,880 18 8134
  G Cons Majority 0.9199 0.0007 0.9087 0.9320 0.8861 210 27 3,473,463 253,496 2 507
  1. The results of our method for the three different evaluation measures are shown in boldface