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Table 4 The significant connections returned from sscMap using the breast cancer optimal gene signature based on the case study with dataset GSE15852, comparing 43 breast tumors with their paired normal tissues

From: A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping

Compound

Replicates

cscore

p value

zscore

SM

PS

IC-86621

4

–0.079

5.0E-06

–4.84

1

1.00

Trichostatin A

182

–0.080

5.0E-06

–4.07

1

1.00

Semustine

4

–0.082

1.0E-04

–3.82

1

1.00

W-13

2

–0.091

8.0E-05

–3.77

1

1.00

Copper sulfate

4

–0.066

1.5E-04

–3.63

1

1.00

Exemestane

1

–0.136

2.8E-04

–3.58

1

1.00

Vorinostat

12

–0.087

1.9E-04

–3.47

1

1.00

Danazol

4

–0.053

2.5E-04

–3.43

1

1.00

Dexverapamil

1

–0.127

5.8E-04

–3.34

1

1.00

15-delta prostaglandin J2

15

–0.051

6.4E-04

–3.20

1

0.73