Fig. 2

a-b Structure scores from the Structure Surfer database aggregated across all annotated human start codons (a) and stop codons (b). The three nucleotides of the start (ATG) and stop codons (e.g. TAA) occupy nucleotide positions 9–11 on each of the plots respectively. The score at each position is calculated as the average score across all nucleotides at that position relative to the codon. At both starts and stops, we note a dip in secondary structure consistent across experiments indicating that these positions, on average, have lower structure than the nucleotides surrounding them