Table 2 Summary of explained and unexplained sites in the four experimental datasets of protein variation, having run PsychoProt with only physicochemical descriptors
Protein | HA | RNP 1934 | RNP 1968 | TEM-1 |
|---|---|---|---|---|
Source of data | Thyagarajan et al. eLife [7] | Doud et al. Mol Biol Evol [19] | Doud et al. Mol Biol Evol [19] | From Deng et al. [4] |
Sites explained by some descriptor | 29.8Â % | 39.8Â % | 39.6Â % | 29.7Â % |
Unexplained of very low tolerance (k* < 4) | 14.5 % | 15.9 % | 7.4 % | 38 % |
Unexplained of very high tolerance (k* > 16) | 23.9 % | 5.8 % | 19.3 % | 0.4 % |
Unexplained of not extreme tolerance to substitutions | 31.7Â % | 38.8Â % | 33.9Â % | 31.9Â % |