Table 3 Summary of results from the three analyses of structure-consistent protein alignments, using PsychoProt with standard parameters and both descriptor sets 1 (physicochemical properties) and 2 (metabolic descriptors)
Protein | TEM-1β-lactamase | BcII metallo-β-lactamase | Aquaporin-0 |
|---|---|---|---|
Soluble/Membrane and oligomerization state | Soluble monomer | Soluble monomer | Transmembrane tetramer |
PDB ID | 1XPB | 1BC2 | 1SOR |
Source of alignment | From EVFold server | From EVFold server | From Ovchinnikov et al. eLife [25] |
Sites explained by some descriptor | 61.6Â % | 69.6Â % | 61.1Â % |
  Hydrophobicity | 47.5 % | 48.7 % | 52.6 % |
 Two metabolic descriptors | 39.5 % | 27.8 % | 17.0 % |
  Volume | 5.6 % | 11.4 % | 15.6 % |
Unexplained of very low tolerance (k* < 4) | 2.7 % | 4.4 % | 10.4 % |
Unexplained of very high tolerance (k* > 16) | 0 % | 0.9 % | 0 % |
Unexplained of not extreme tolerance to substitutions | 35.7Â % | 25.1Â % | 28.5Â % |