In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy

BMC Bioinformatics

Table 6 Predicted off-targets associated with target KVAELVHFL-HLA-A*02:01 derived from MAGEA3

	Off.target	DoS	IC₅₀	Off.target.gene	Normal.tissue.samples
1	KVAELVHIL	8	103.72	DDX28	Muscle, Skin, BLCA, HNSC
2	KVAELVQFL	8	46.07	MAGEC3	Brain, Spleen, THCA, ESCA
3	KMAELVHFL	8	2.66	MAGEA12	Brain, Muscle, BLCA, HNSC
4	SAAELVHFL	7	187.05	EPS8L2	Esophagus, Kidney, HNSC, STAD
5	KLEELVHFL	7	11.98	MRVI1	Blood Vessel, Blood, ESCA, STAD
6	SAADLVHFL	6	211.83	EPS8	Blood Vessel, Adipose Tissue, COAD, READ

The table lists the off-target peptides, degree of similarity of the off-target peptides with the target peptide, binding affinity (IC₅₀ in nanomolars) of peptide-HLA-A*02:01 complexes involving the off-target peptides, genes from which the off-target peptides were derived, and the essential, normal tissue types from GTEx and TCGA with high expression of the off-target peptides/genes

ISSN: 1471-2105