Fig. 2

Performance comparison of two thresholding strategies of the ensemble framework on two yeast PINs. Five centrality measures (BC, CC, DC, EC and SC) are used as the base models respectively. We also compared our ensemble methods with: 1) using a single PCC-thresholded PIN with thr = 0.75, and 2) using a PCC-weighted version of PIN. Proteins are ranked according to their final scores calculated by each ensemble method (i.e., EnBC, EnCC, EnDC, EnEC and EnSC) or by each centrality measure (BC, CC, DC, EC and SC) or by the other compared methods. For each ensemble method on each case, top n ranked proteins are selected as the candidates of essential proteins, out of which the number of true essential proteins are determined. The same procedure is applied to five centrality measures and the other compared methods