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Table 4 Running time (seconds) for warm-start versus cold-started gene essentiality analysis in quad-precision using Quad MINOS (one LP is run for each reaction at a single growth rate)

From: solveME: fast and reliable solution of nonlinear ME models

Model Genes Warm-start Cold-start Speed-up
E. coli ME (reduced) 1424 3130.8 58967.4 19×
T. maritima ME [3] 613a 5.26 h >60 h 12×
  1. aOnly the 613 genes coding for proteins forming functional complexes were tested for essentiality