Fig. 3

Cell-fate decision model. a Cell-fate decision model [11] used as gold standard. Essential nodes are shown with grey background. b List of transitions, starting from each of the 4 unperturbed network’s attractors to attractors reached after single node perturbations of the cell-fate decision model. Each line corresponds to an edge in the attractor reachability graph. Only the first lines are shown, the full table is given in Additional file 3. c PKN obtained from (b) by adding edges from perturbed nodes to observed nodes whose state (absolute value) change by more than 0.5 (highlighted in yellow). Edges are positive if perturbation and variation of observed node state have same sign, and negative if they have opposite sign. For example, line 3 in table (b) will generate seven positive edges from Apoptosome to Apoptosis, BAX, CASP3, CASP8, Cyt_c, MOMP and SMAC as well as one negative edge from Apoptosome to cIAP. The complete list of interactions in the PKN is given in Additional file 4 (PKN 1)