Fig. 1
From: Integration of metabolomics, lipidomics and clinical data using a machine learning method
The design of the PPAR-pan agonist treatment study. a Four week old Sprague Dawley rats were acclimatised for approximately 3 weeks and were killed after a 13 week dose period. b Recovery animals were acclimatised for 3 weeks, dosed with the test compound for 13 weeks and kept for an additional 4 week dose free period. Before terminal kills urine and plasma samples were collected for urinalysis and clinical chemistry. After the terminal kills liver weight were recorded and liver samples were collected for metabolomic analysis