Fig. 2

A global view of the chromatin modification patterns encoded in association rules. a All epigenetic signatures of chromatin modifications and Pattern 155. Each row corresponds to an association rule (i.e. a pattern or a combination of chromatin modification) and each column to a chromatin modification mark. Rules (556 for promoters and 1852 gene bodies) are clustered by chromatin modification marks. The colour in each cell indicates the differential change of marks in the livers of normal and HBx-transgenic mice. Light green and light red represent the extreme chromatin modification changes, e.g. hypo or hyper methylation of histone, respectively. The epigenetic signatures were tightly clustered into two groups, representing the modified and unmodified states of chromatin. Association rules in the yellow rectangles represent the epigenetic signatures of Pattern 155, which constitutes the combination of the loss of H3K4Me3 and the gains of H3K27Me3 and H3K36Me3. b Plots for the support and lift of the association rules. The grey scale represents the confidence levels and the coloured rectangles correspond to supersets of Pattern 155, which contained the three modified states of Pattern 155 as well as other chromatin marks. The rule length, which corresponds to the number of modified states, is > 3. Red, yellow, and blue rectangles correspond to rule length 3, 4, and 5, respectively