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Fig. 6 | BMC Bioinformatics

Fig. 6

From: ChARM: Discovery of combinatorial chromatin modification patterns in hepatitis B virus X-transformed mouse liver cancer using association rule mining

Fig. 6

Relationships between histone methylations, PolII, DNA methylation, and gene expression. a Relationships between PolIIS5 changes and each of three histone methylation marks in the promoters. b Relationships between DNA methylation and histone methylation in gene bodies. In (a) and (b), a green background represents the changes of all transcripts, while red (H3K4Me3), blue (H3K27Me3), and purple (H3K36Me3) rectangles represent the changes of (a) P155s and (b) G155s. Yellow rectangles in each plot correspond to the genes for which (a) PolIIS5 or (b) DNA methylation decreased (dRES < −0.5). c Gene expression in normal and HBx TG mouse livers, as measured by RNA-seq and exon array (Additional file 4: Figure S3). The majority of genes in P155 were not differentially expressed (grey dots). Among the differentially expressed genes in P155, substantially more genes were down-regulated (dark green dots) than up-regulated (red dots)

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BMC Bioinformatics

ISSN: 1471-2105

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