Disease gene prioritization by integrating tissue-specific molecular networks using a robust multi-network model

BMC Bioinformatics

Table 2 AUC value comparison

Network model	Method	AUC50	AUC100	AUC300	AUC500	AUC700	AUC1000
Heterogeneous network	CIPHER-DN	0.2332***	0.2439***	0.2510***	0.2524***	0.2530***	0.2535***
	CIPHER-SP	0.2068***	0.2478***	0.3112***	0.3369***	0.3568***	0.3790***
	RWRH	0.2382***	0.2849***	0.3849***	0.4503**	0.4922**	0.5388**
	PRINCE	0.2632*	0.3065*	0.3787**	0.4247***	0.4594***	0.5092***
	BIRW	0.2615*	0.3082*	0.4095*	0.4653	0.5068*	0.5513*
	Katz	0.2101***	0.2726***	0.3831**	0.4451*	0.4838**	0.5289**
	CATAPULT	0.1370***	0.1957***	0.3148***	0.3803***	0.4315***	0.4875***
NoN	CR	0.2711*	0.3235	0.4244	0.4815	0.5233	0.5665
NoSN ^a	CRstar	*0.2900*	*0.3408*	*0.4347*	*0.4890*	*0.5331*	*0.5779*
NoSN ^b	CRstar	0.2900	0.3400	0.4355	0.4882	0.5331	0.5798
	WCRstar	*0.2906*	*0.3409*	*0.4384*	*0.4973*	*0.5415*	*0.5863*

^aNoSN with one set of tissue-specific GCNs. ^bNoSN with two sets of tissue-specific GCNs. The p-value ranges: * represents 0.005∼0.05, ** represents 0.0005∼0.005, *** represents <0.0005

ISSN: 1471-2105