Table 3 The list of pathways that rank higher in ContextTRAP than in TRAP
From: Prioritizing biological pathways by recognizing context in time-series gene expression data
Dataset | Pathway name | Rank | Description | Ref |
|---|---|---|---|---|
H5N1 | JAK-STAT signaling pathway | 3→2 | The challenging respiratory epithelial cells with hemagglutinin of H5N1 exploit the JAK2/3/STAT1 and result in a large release of cytokines, initiating a destructive innate immune response. | [36] |
|  | PI3k-Akt signaling pathway | 6→5 | PI3K-Akt signaling, which can be activated by the NS1 protein of H5N1, is crucial for viral replication. | [43] |
|  | Apoptosis | 139→31 | Apoptosis plays a major role in the pathogenesis of H5N1 virus in humans by destroying alveolar epithelial cells. | [44] |
Th17 | Cytokine-cytokine receptor interaction | 33→10 | The differentiation of T H 17 cells from naive CD4 + T cells is regulated by multiple cytokines. | [38] |
|  | MAPK signaling pathway | 47→40 | MAPKs play a supplemental role in mediating the intracellular responses to TGF- β required for differentiation of T H 17. | [39] |
|  | Toll-like receptor signaling pathway | 46→41 | Differentiation of T H 17 cell is induced by proinflammatory cytokines generated by ligation of a subset of toll-like receptors. | [41] |