Table 2 Performance of the proposed sequence-based methods on the 9 types of ligands over five-fold cross-validation and comparison with S-SITE
From: Protein ligand-specific binding residue predictions by an ensemble classifier
Ligand | w a | Method | Accuracy (%) | Sensitivity (%) | Specificity (%) | MCC |
|---|---|---|---|---|---|---|
CU | 15 | TargetSeq | 99.02 | 51.40 | 99.69 | 0.59 |
S-SITE | 97.98 | 60.37 | 98.50 | 0.46 | ||
FE | 9 | TargetSeq | 98.83 | 53.54 | 99.52 | 0.57 |
S-SITE | 96.93 | 59.55 | 97.49 | 0.38 | ||
FE2 | 9 | TargetSeq | 99.20 | 51.36 | 99.81 | 0.63 |
S-SITE | 98.28 | 42.14 | 99.00 | 0.37 | ||
ZN | 11 | TargetSeq | 99.01 | 41.78 | 99.68 | 0.50 |
S-SITE | 97.71 | 56.43 | 98.20 | 0.38 | ||
SO4 | 13 | TargetSeq | 97.79 | 10.07 | 99.66 | 0.19 |
S-SITE | 96.98 | 14.4 | 98.73 | 0.15 | ||
PO4 | 7 | TargetSeq | 98.09 | 20.18 | 99.59 | 0.31 |
S-SITE | 97.29 | 27.86 | 98.63 | 0.27 | ||
ATP | 19 | TargetSeq | 97.14 | 36.81 | 99.31 | 0.48 |
S-SITE | 96.73 | 48.09 | 98.48 | 0.49 | ||
FMN | 17 | TargetSeq | 97.23 | 56.59 | 99.32 | 0.66 |
S-SITE | 96.39 | 66.56 | 97.92 | 0.62 | ||
HEME | 17 | TargetSeq | 92.62 | 61.27 | 95.26 | 0.53 |
S-SITE | 93.63 | 58.24 | 96.61 | 0.55 |