Fig. 4

– Enrichment and depletion in TF-TF interactions. The figure illustrates cases of enrichment (red plus) and depletion (blue minus) relative to random expectation for TF-TF interactions between classes of regulatory function, based on data related to a DNA binding and b PPI. For each pair of regulatory functions (Pioneers (P), Settlers (S), positive Migrants (M+) and negative Migrants (M-)) the enrichment or depletion is indicated for each of the data sources, 2× DNA binding in a) and 2× PPI in b). The strongest tendency is that interactions involving in particular Pioneers tend to be enriched in DNA-based interactions, whereas interactions involving in particular positive Migrants tend to be depleted in DNA-based interactions and enriched in PPIs