Fig. 9

Detailed dynamics of specific memory B cells in the PN model and in the UISS computational framework. Memory B cells levels obtained with the PN model are in good agreement (from a qualitative point of view) with the results obtained by using the UISS framework. The drop in the number of memory B cells in the PN model just after the second injection is caused by the fact that, after the second injection of bacteria, all memory cells are temporarily enrolled into the interaction with bacterial antigens, and rapidly move inside the relative transition (AG_MEM_B transition in Fig. 6). This leaves for a short time the relative place without memory cells. As a result of this, since we actually plot only tokens that are in places, for a very short time the relative curve goes down