BMC Bioinformatics

Table 5 Average a-helix contents (%) from DSSP analysis for 1mof, 1mof-I54D, 2wrp, and 2wrp-H16I at different temperatures

From: A hydrophobic spine stabilizes a surface-exposed α-helix according to analysis of the solvent-accessible surface area

whole protein
	300 K	p-value	400 K	p-value	500 K	p-value
1mof	51.27	>0.001	22.46	>0.001	4.80	>0.001
1mof-I54D	43.38	>0.001	21.81	>0.001	5.42	>0.001
2wrp	65.44	>0.001	48.03	>0.001	4.62	>0.001
2wrp-H16I	61.51	>0.001	42.41	>0.001	13.86	>0.001
hydrophobic spine regions
1mof	30.85	>0.001	11.61	>0.001	3.64	>0.001
1mof-I54D	29.95	>0.001	10.20	>0.001	1.61
2wrp	13.71	>0.001	11.52	>0.001	1.30	0.84
2wrp-H16I	13.26	>0.001	12.29	>0.001	1.12	0.84

The boldface indicates the significant difference after Bonferroni correction

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ISSN: 1471-2105

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