Table 3 Top 20 targets predicted for Aripiprazole and Theophylline

1

5-hydroxytryptamine receptor 2A

1

cAMP-specific 3’,5’-cyclic phosphodiesterase 4A

2

Alpha-1B adrenergic receptor

2

Histone deacetylase 2

3

Muscarinic acetylcholine receptor M2

3

Adenosine receptor A2a

4

5-hydroxytryptamine receptor 2C

4

Adenosine receptor A1

5

D(1) dopamine receptor

5

cGMP-inhibited 3’,5’-cyclic phosphodiesterase A

6

Alpha-2C adrenergic receptor

6

cAMP-specific 3’,5’-cyclic phosphodiesterase 4B

7

Histamine H1 receptor

7

Adenosine receptor A2b

8

Muscarinic acetylcholine receptor M3

8

cGMP-specific 3’,5’-cyclic phosphodiesterase

9

D(2) dopamine receptor

9

Adenosine receptor A3

10

Muscarinic acetylcholine receptor M1

10

Thymidylate synthase

11

5-hydroxytryptamine receptor 1B

11

Histone deacetylase 1

12

Delta-type opioid receptor

12

Cyclin-dependent kinase 2

13

D(4) dopamine receptor

13

Reverse transcriptase/RNaseH

14

D(3) dopamine receptor

14

Cap-specific mRNA (nucleoside-2’-O-)-methyltransferase

15

5-hydroxytryptamine receptor 1D

15

Multi-sensor signal transduction histidine kinase

16

Alpha-1 adrenergic receptor

16

Alpha-1 adrenergic receptor

17

Muscarinic acetylcholine receptor M5

17

Serine/threonine-protein kinase pim-1

18

Muscarinic acetylcholine receptor M4

18

Serine-protein kinase ATM

19

Alpha-2B adrenergic receptor

19

Proto-oncogene tyrosine-protein kinase Src

20

5-hydroxytryptamine receptor 1A

20

Phosphatidylinositol 4,5-bisphosphate 3-kinase

catalytic subunit alpha isoform