Fig. 2

Examples of kinome tree annotation created by KinMap. a Inhibition profiles of two approved drugs sorafenib (orange circles) and sunitinib (creme circles) [4], and kinases linked to thyroid carcinoma (blue squares) and colonic neoplasm (red squares) as extracted from the CTTV platform [14]. b Availability of structural and bioactivity data for the human kinome; red circles: number of structures per kinase in the PDB [11]; blue circles: number of activity measurements for the respective kinase in ChEMBL [12]; green triangles: key targets of clinically approved kinase inhibitors [12]