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Table 1 List of in silico prediction algorithms and conservation scores summarized through the Genome Tolerance Browser

From: GTB – an online genome tolerance browser

Non-Synonymous Prediction Algorithms
Generic Cancer-Specific
SIFT TransFIC (SIFT)
PolyPhen-2 (HumVar & HumDiv) TransFIC (PolyPhen-2)
MutationAssessor TransFIC (MutationAssessor)
FATHMM (Unweighted & Weighted) FATHMM (Cancer)
FATHMM-MKL (Coding)  
MutationTaster2  
PROVEAN  
VEST  
LRT  
MetaLR  
MetaSVM  
Genome-Wide Prediction Algorithms
CADD  
DANN  
FATHMM-MKL (Non-coding)  
fitCons  
Conservation Scores
PhastCons (46-Way)  
PhyloP (46-way; vertebrate, primates and placental mammals)
PhastCons (100-Way)  
PhyloP (100-way; vertebrate, primates and placental mammals)
GERP++  
SiPhy