Table 1 List of in silico prediction algorithms and conservation scores summarized through the Genome Tolerance Browser
Non-Synonymous Prediction Algorithms | |
|---|---|
Generic | Cancer-Specific |
SIFT | TransFIC (SIFT) |
PolyPhen-2 (HumVar & HumDiv) | TransFIC (PolyPhen-2) |
MutationAssessor | TransFIC (MutationAssessor) |
FATHMM (Unweighted & Weighted) | FATHMM (Cancer) |
FATHMM-MKL (Coding) | |
MutationTaster2 | |
PROVEAN | |
VEST | |
LRT | |
MetaLR | |
MetaSVM | |
Genome-Wide Prediction Algorithms | |
CADD | |
DANN | |
FATHMM-MKL (Non-coding) | |
fitCons | |
Conservation Scores | |
PhastCons (46-Way) | |
PhyloP (46-way; vertebrate, primates and placental mammals) | |
PhastCons (100-Way) | |
PhyloP (100-way; vertebrate, primates and placental mammals) | |
GERP++ | |
SiPhy | |