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Table 1 Loci attaining genome-wide significance (p <5×10−8) in META-SCOPA meta-analysis of GWAS of lipid traits and BMI in 1,441 individuals from the Estonian Genome Center, University of Tartu

From: SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes

Locus

Lead SNP

Chr

Positiona (bp)

Alleles

EAF

META-SCOPA

Effect

Other

BMI effect (SE)

HDL effect (SE)

LDL effect (SE)

TG effect (SE)

p-value

APOE

rs7412

19

45,412,079

T

C

0.102

−0.017 (0.011)

−0.046 (0.011)

0.129 (0.011)

−0.078 (0.012)

3.4×10−32

CETP

rs56156922

16

56,987,369

C

T

0.308

−0.026 (0.017)

−0.119 (0.018)

0.046 (0.017)

−0.024 (0.019)

2.4×10−10

GPC5

rs71427535

13

92,826,439

C

T

0.108

0.007 (0.011)

0.014 (0.012)

0.024 (0.011)

−0.065 (0.012)

1.1×10−8

LIPC

rs2043085

15

58,680,954

T

C

0.343

−0.022 (0.019)

−0.124 (0.020)

0.013 (0.019)

−0.070 (0.020)

1.9×10−8

  1. Chr: chromosome. SE: standard error. EAF: effect allele frequency
  2. aPosition reported for NCBI build GRCh37 (UCSC hg19 assembly)