SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes

Table 3 Dissection of multiple phenotype association signals for lead SNPs from META-SCOPA meta-analysis of GWAS of lipid traits and BMI in 1,441 individuals from the Estonian Genome Center, University of Tartu

Model	Difference in BIC from null model
Model	APOE: rs7412	CETP: rs56156922	GPC5: rs71427535	LIPC: rs2043085
BMI	10.29	12.64	12.99	12.73
HDL	10.85	−28.53	0.06	−14.75
LDL	−86.12	7.26	8.86	10.31
TG	7.18	9.36	−21.69	11.95
BMI + HDL	20.75	−17.41	13.01	−3.44
BMI + LDL	−76.28	19.96	21.91	23.01
BMI + TG	17.67	21.95	−9.23	24.61
HDL + LDL	−75.72	−21.24	9.37	−3.94
HDL + TG	14.04	−15.75	−10.66	−13.61
LDL + TG	−105.91	18.66	−17.68	21.70
BMI + HDL + LDL	−66.14	−10.18	22.26	7.25
BMI + HDL + TG	24.27	−4.57	1.50	−1.62
BMI + LDL + TG	−95.35	31.31	−5.21	34.30
HDL + LDL + TG	−108.01	−10.02	−5.82	−4.07
BMI + HDL + LDL + TG	−97.59	1.25	6.33	7.94

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