Fig. 1

Trajectory of the transcriptomes: Axes represent principal components explaining 95.7% of the variability in the data. Measurement points represent the entire transcriptome under three different stimulation experiments projected onto the first three principal components. For early time periods, all three transcriptomes correlate very well with each other. Over time, the transcriptomes develop stimulus dependent. Stimulus 1 leads to a strong change in the transcriptome, while stimulus 2 has a much smaller effect. Possible outliers are measurement points that show a large distance from the trajectory or from related replicates