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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Multiple network algorithm for epigenetic modules via the integration of genome-wide DNA methylation and gene expression data

Fig. 1

Flowchart of the proposed algorithm. a The common modules in both gene expression and methylation networks are defined as the functional epigenetic modules, (b) EMDN consists of two major components: differential network construction and functional epigenetic module discovery. The differential network construction consists of two steps: First, the coexpression (comethylation) network is constructed using the gene expression (methylation) profiles, then the p-values of gene expression (methylation) between tumor and non-tumor samples are incorporated into the coexpression (comethylation) network to develop the differential networks. Finally, the algorithm discovers the common modules in multiple differential networks

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BMC Bioinformatics

ISSN: 1471-2105

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